MD ANDERSON THERAPEUTICS DISCOVERY DIVISION
Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.
The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.
The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation’s leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.
The Institute for Applied Cancer Science is seeking a highly motivated and team oriented individual to be join our ADME/PK research group to support the Institute for Applied Cancer Sciences fast-paced drug discovery programs. The position requires a high self-motivated individual, with organizational skills, and the ability to effectively present results and conclusions to co-workers and managers. A collaborative attitude is essential for this position.
The ideal candidate will have experience in ADME assays using biomatrix such as plasma, microsomes and hepatocytes, working on plasma and tumor tissue PK samples, using automation and SPE (solid phase extraction) for sample processing, and analyzing samples using LC-MS/MS instruments.
JOB SPECIFIC COMPETENCIES
• Under minimal supervision, process plasma, tumor and any other tissue samples using liquid handling automation systems or solid phase extraction (SPE) for liquid chromatography mass spectrometry (LC-MS) analysis.
• Conduct in vitro ADME incubation assays such as plasma stability assay, microsomal stability assay, hepatocyte incubation, and plasma-protein binding assay.
• Conduct LC-MS/MS method development of new small molecule drug candidate compounds.
• Use LC-MS for sample analysis, data acquisition, data analysis, and generate final bioanalytical reports.
• Conduct routine LC-MS instrument maintenance and performance check.
• Employ safe lab practices.
• Maintain research records and laboratory notes.
• Participate in integrated drug discovery research project teams.
Required: Bachelor’s degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Required: One year of relevant research experience in lab. With preferred Master’s degree, no required experience.
Preferred: Three years’ experience in cell culture, enzymology, analytical chemistry, pharmacology, or other relevant fields such as pharmaceutical, biological or chemical sciences is preferred. The ideal candidate will have experience in ADME assays using biomatrix such as plasma, microsomes and hepatocytes, working on plasma and tumor tissue PK samples, using automation and SPE (solid phase extraction) for sample processing, and analyzing samples using LC-MS/MS instruments and will have Strong work ethics, good interpersonal skills and oral/written skills.