The Gifford lab in the Departments of Pediatrics and Genetics, and the BASE Institute is seeking a highly motivated Life Science Research Professional 2 to join us in our study of the complex genetic and molecular mechanisms involved in cardiovascular development and disease.
The ultimate goal of our lab is to make precision medicine a reality for cardiovascular disease patients. We use pluripotent stem cell and animal models to define the genes and regulatory elements necessary for cell fate decisions and to probe how variation in these sequences can lead to congenital heart disease. Experimental approaches utilized include various RNA-sequencing modalities (e.g. single-cell, nascent RNA), ChIP-sequencing, chromatin accessibility measurements (e.g. ATAC-sequencing), and high-throughput CRISPR screens. Integrative analyses are performed using cutting-edge advances in machine learning to reveal disease-causing variants and mechanisms. We work closely with physicians to ensure our experimental plans will solve critical problems faced by patients.
We are seeking a creative, driven, organized individual to aid in the design and implementation of these experiments. The LSRP2 will collaborate with the other team members to develop protocols, perform experiments, and evaluate and interpret results.
The candidate for this position should have experience with standard molecular biology techniques and mammalian cell culture; excellent communication, organization, and time management skills; and the ability to think creatively to solve problems.