Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression. The company has advanced losmapimod to Phase 2 clinical development for the treatment of facioscapulohumeral muscular dystrophy (FSHD). Fulcrum has also advanced FTX-6058, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and beta thalassemia into Phase 1 clinical development.
As a Research Associate, you will be expected to work equally well as a self-starter and as a member of a matrixed team within Fulcrum. Your focus will be to develop, implement, and execute in vitro assays required for the advancement of high priority projects. You will work in close collaboration with other scientists to drive pre-clinical target discovery and target validation in a variety of diseases. This role is ideal for an individual with the desire to learn, tackle new challenges, and directly impact the development of novel therapies for patients.
- Develop and execute appropriate in vitroassays required for the advancement of high priority projects with firm deadlines
- Work closely with other members of the research team to validate/invalidate and prioritize targets in monogenic diseases using chemical probe and genetic approaches
- Analyze, discuss, and present results as part of an interdisciplinary project team
- Communicate effectively within a cross-functional team of cell and molecular biologists, data scientists, and business development leaders
- Maintain accurate and timely documentation and organization of experiments and data
- BS or MS in life sciences with 2-3+ years relevant experience in an academic or industry setting
- Strong background hands-on experience with cell culture, assay development, gene expression analysis, protein analysis and general molecular biology techniques.
- Experience with using knockdown or over-expression techniques in in vitromodels including CRISPR, shRNA, ASO or lentiviral overexpression.
- Demonstrated attention to detail, high standards for experimental accuracy, and proven follow-through on assigned activities
- Ideal candidates are creative problem-solvers with a get-it-done attitude who can thrive independently or as part of a team
- Expertise in primary cell disease models with a track record in assay development, implementation, and execution
- Familiarity with mammalian cell biology and experimental techniques (cellular differentiation, immunocytochemistry, fluorescence microscopy)
- Previous experience with lab automation